Fibrinogen-like Protein 1 (FGL1): Major Immune Inhibitory Ligand of LAG-3

FGL1 is identified as a major ligand for the inhibitory receptor LAG-3, and its blockade can potentiate anti-tumor T cell responses.
? FGL1 is a major ligand of LAG-3 that mediates T cell suppression
? FGL1 is normally released by the liver in low levels but by cancer in high levels
? Blockade of the FGL1-LAG-3 interaction potentiates antitumor immunity

Recombinant Human FGL1 protein reagent

Catalogue No. Product description Species Tag Expression host Size
13484-H08B Recombinant FGL1 protein Human His Baculovirus-Insect Cells 20μg / 100μg

High purity:

>90% as determined by SDS-PAGE

Validated binding activity:

Measured by its ability to bind with human LAG3 (Cat:16498-HNAH)
in a functional ELISA.

FGL1 receptor LAG-3 proteins & antibodies

Biotinylated LAG-3 protein

Catalogue No. Product description Species Tag Expression host Size
16498-HNAH-B Biotinylated LAG3 Protein Human Native HEK293 Cells 20μg / custom size

More recombinant LAG-3 protein

Catalogue No. Species Tag Expression host Size
16498-HNAH Human Native HEK293 Cells 50μg? / 200μg?
16498-H08H Human His tag HEK293 Cells 50μg? / 200μg?
16498-H05H Human Fc tag HEK293 Cells 50μg? / 200μg?
16498-H02H Human Fc tag HEK293 Cells 50μg? / 200μg?
53069-M02H Mouse Fc tag HEK293 Cells 50μg? / 200μg?
53069-M02H4 Mouse Fc tag HEK293 Cells 50μg? / 200μg?
53069-M08H Mouse His tag HEK293 Cells 50μg? / 200μg?
53069-M08H3 Mouse His tag HEK293 Cells 50μg? / 200μg?
80367-R08H Rat His tag HEK293 Cells 50μg? / 200μg?
90841-C08H Cynomolgus His tag HEK293 Cells 50μg? / 200μg?

Anti LAG-3 antibody

Catalogue No. Product description Application Dulition Specificity
53069-T16 Anti-LAG3 Antibody, Rabbit Pab ELISA 1:5000-1:10000 Mouse LAG3

FGL1 research reference

? Wang et al.Fibrinogen-like Protein 1 Is a Major Immune Inhibitory Ligand of LAG-3,2019, Cell 176, 1–14
? Nagdas SK, Winfrey VP, Olson GE.Two fibrinogen-like proteins, FGL1 and FGL2 are disulfide-linked subunits of oligomers that specifically bind nonviable spermatozoa.Int J Biochem Cell Biol. 2016 Nov;80:163-172
? Nayeb-Hashemi H, Desai A,et al.Targeted disruption of fibrinogen like protein-1 accelerates hepatocellular carcinoma development.Biochem Biophys Res Commun. 2015 Sep 18;465(2):167-73.

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