Non-Canonical Wnt Pathway

Non-Canonical Wnt Pathway Background

Intracellular signaling of the Wnt pathway diversifies into at least three branches: (1) the β-catenin pathway (canonical Wnt pathway), which activates target genes in the nucleus; (2) the planar cell polarity pathway, which involves jun N-terminal kinase (JNK); and (3) the Wnt/Ca2+ pathway. The last two kinds can be classified into the non-canonical Wnt pathways. In the planar cell polarity pathway, frizzled activates JNK and directs asymmetric cytoskeletal organization and coordinated polarization of cells within the plane of epithelial sheets. This pathway involves the Fmi, Knyand Stbm The Wnt/Ca2+ pathway leads to release of intracellular Ca2+, possibly via G-proteins. This pathway involves activation of PLC and PKC. Elevated Ca2+ can activate the phosphatase calcineurin, which leads to dephosphorylation of the transcription factor NF-AT and its accumulation in the nucleus.

Contact us

彩票大奖得主捐赠 山西11选5前三走势图 山东老十一选五走势 幸运农场公式预测 江西多乐彩综合走势图 股票行情康新欣材 吉林十一选五跨度走势图 欢享斗地主挂怎么安装 幸运农场是不是正规的 一个老彩民的心得 浙江20选5走试图连线