Subunit structure: Binds PTPN6 when phosphorylated.
Domain: Contains 3 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
Subcellular location: Cell membrane {ECO:0000269|PubMed:9151699}; Single-pass type I membrane protein {ECO:0000269|PubMed:9151699}. Note=Ligand binding leads to internalization and translocation to an antigen-processing compartment.
Tissue specificity: Detected in monocytes, macrophages, dendritic cells, lung, natural killer cells and B-cells. {ECO:0000269|PubMed:9151699, ECO:0000269|PubMed:9278324, ECO:0000269|PubMed:9548455}.
Induction: Upon contact with CD8(+)CD28(-) alloantigen-specific T suppressor (Ts) cells.
Sequence similarity: Contains 2 Ig-like C2-type (immunoglobulin-like) domains. {ECO:0000305}.General information above from UniProt