Azurocidin / CAP37 (Protein | Antibody | cDNA Clone | ELISA Kit)

All Azurocidin / CAP37 reagents are produced in house and quality controlled, including 5 Azurocidin / CAP37 Antibody, 2 Azurocidin / CAP37 ELISA, 13 Azurocidin / CAP37 Gene, 1 Azurocidin / CAP37 Lysate, 1 Azurocidin / CAP37 Protein, 1 Azurocidin / CAP37 qPCR. All Azurocidin / CAP37 reagents are ready to use.

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Azurocidin / CAP37 Related Research Area

Azurocidin / CAP37 Background

Azurocidin (AZU1), also known as heparin-binding protein (HBP) or cationic antimicrobial protein 37 (CAP37), is an azurophil granule antibiotic protein, with monocyte chemotactic and antibacterial activity. The Azurophil granules, specialized lysosomes of the neutrophil, contain at least 1 proteins implicated in the killing of microorganisms. Azurocidin is a member of the serine protease family that includes Cathepsin G, neutrophil elastase (NE), and proteinase 3 (PR3), however, Azurocidin is not a serine proteinase since the active site serine and histidine residues are replaced. Neutrophils arriving first at sites of inflammation release Azurocidin, which acts in a paracrine fashion on endothelial cells causing the development of intercellular gaps and allowing leukocyte extravasation. It thus be regarded as a reasonable therapeutic target for a variety of inflammatory disease conditions.

Azurocidin / CAP37 References

  • Lindmark A, et al. (1999) Characterization of the biosynthesis, processing, and sorting of human HBP/CAP37/azurocidin. J Leukoc Biol. 66(4): 634-43.
  • Heinzelmann M, et al. (2001) Heparin binding protein (CAP37) differentially modulates endotoxin-induced cytokine production. Int J Surg Investig. 2(6): 457-66.
  • Soehnlein O, et al. (2005) Neutrophil-derived heparin-binding protein (HBP/CAP37) deposited on endothelium enhances monocyte arrest under flow conditions. J Immunol. 174(10): 6399-405.
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