YES1 (Protein | Antibody | cDNA Clone | ELISA Kit)

All YES1 reagents are produced in house and quality controlled, including 1 YES1 Antibody, 13 YES1 Gene, 1 YES1 Lysate, 1 YES1 Protein. All YES1 reagents are ready to use.

YES1 Background

Proto-oncogene tyrosine-protein kinase Yes, also known as Proto-oncogene c-Yes, p61-Yes and YES1, is a cytoplasm protein which belongs to theprotein kinase superfamily, Tyr protein kinase family and SRC subfamily. YES1 / c-Yes contains oneprotein kinase domain, oneSH2 domain and oneSH3 domain. It is thought that the subcellular distribution of Src-family tyrosine kinases, including c-Yes binding to the cellular membrane, is membranous and/or cytoplasmic. YES1 / c-Yes protein tyrosine kinase is known to be related to malignant transformation. YES1 / c-Yes and c-Src are the two most closely related members of the Src family of nonreceptor tyrosine kinases. Although there is much evidence to support redundancy in signaling between these two kinases. YES1 / c-Yes promotes formation of the tight junction by phosphorylating occludin, while c-Src signaling downregulates occludin formation in a Raf-1 dependent manner. YES1 / c-Yes has tyrosine kinase activity. It promotes infectivity of Neisseria gonorrhoeae in epithelial cells by phosphorylating MCP / CD46.

YES1 References

  • Summy,J.M. et al., 2003, Front Biosci  8 :s185-205.
  • Clump,D.A. et al., 2005, Growth Factors  23 (4):263-72.
  • Nonomura,T. et al., 2007,Int J Oncol  30 (1):105-11.
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