DR4 / TRAIL R1 (Protein | Antibody | cDNA Clone | ELISA Kit)

All DR4 / TRAIL R1 reagents are produced in house and quality controlled, including 9 DR4 / TRAIL R1 Antibody, 1 DR4 / TRAIL R1 ELISA, 15 DR4 / TRAIL R1 Gene, 3 DR4 / TRAIL R1 Lysate, 3 DR4 / TRAIL R1 Protein, 1 DR4 / TRAIL R1 qPCR. All DR4 / TRAIL R1 reagents are ready to use.

DR4 / TRAIL R1 Background

Tumor necrosis factor receptor superfamily, member 1a (TRAIL R1), also known as TRAIL receptor 1 (TRAIL R1) or CD261 antigen, is a member of the TNF-receptor superfamily. This receptor is activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF1/TRAIL), and thus transduces cell death signal and induces cell apoptosis. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. TRAIL R1/CD261/TNFRSF1A serves as a receptor for the cytotoxic ligand TNFSF1/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. TRAIL R1 can promote the activation of NF-kappa-B. TRAIL R1/CD261/TNFRSF1A induces apoptosis of many transformed cell lines but not of normal tissues, even though its death domain-containing receptor, DR4, is expressed on both cell types.

DR4 / TRAIL R1 References

  • Kimberley FC, et al. (2005) Following a TRAIL: update on a ligand and its five receptors.". Cell Res. 14 (5): 359–72.
  • Schneider P, et al. (1997) Characterization of two receptors for TRAIL.". FEBS Lett. 416 (3): 329–34.