TIM-1 / KIM-1 (Protein | Antibody | cDNA Clone | ELISA Kit)

All TIM-1 / KIM-1 reagents are produced in house and quality controlled, including 27 TIM-1 / KIM-1 Antibody, 4 TIM-1 / KIM-1 ELISA, 52 TIM-1 / KIM-1 Gene, 13 TIM-1 / KIM-1 Lysate, 13 TIM-1 / KIM-1 Protein, 3 TIM-1 / KIM-1 qPCR. All TIM-1 / KIM-1 reagents are ready to use.

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TIM-1 / KIM-1 Background

HAV cellular receptor 1 (HAVCR1), also known as Kidney injury molecule 1 (KIM-1) and T cell immunoglobulinmucin 1 (TIM-1), is a type â… integral membrane glycoprotein. KIM-1 protein is widely expressed with highest levels in kidney and testis. It has been shown to play a major role as a human susceptibility gene for asthma, allergy and autoimmunity. IgA1lambda is a specific ligand of KIM-1 protein and that their association has a synergistic effect in virus-receptor interactions. KIM-1 involves in the pathogenesis of acute kidney injury. It had been confirmed that KIM-1 is a human urinary renal dysfunction biomarker. Moreover, KIM-1 protein is a novel regulatory molecule of flow-induced calcium signaling.

TIM-1 / KIM-1 References

  • Tami C, et al. (2007) Immunoglobulin A (IgA) is a natural ligand of hepatitis A virus cellular receptor 1 (HAVCR1), and the association of IgA with HAVCR1 enhances virus-receptor interactions. J Virol. 81(7): 3437-46.
  • Rees AJ, et al. (2008) Kim-1/Tim-1: from biomarker to therapeutic target? Nephrol Dial Transplant. 23(11): 3394-6.
  • Chaturvedi S, et al. (2009) Assay validation for KIM-1: human urinary renal dysfunction biomarker. Int J Biol Sci. 5(2): 128-34.
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