IL-6R (Protein | Antibody | cDNA Clone | ELISA Kit)

All IL-6R reagents are produced in house and quality controlled, including 15 IL-6R Antibody, 4 IL-6R ELISA, 41 IL-6R Gene, 7 IL-6R Lysate, 7 IL-6R Protein, 2 IL-6R qPCR. All IL-6R reagents are ready to use.

IL-6R Background

Interleukin 6 receptor (IL-6R) also known as CD126 (Cluster of Differentiation 126) is a type I cytokine receptor. The low concentration of a soluble form of IL-6 receptor (sIL-6R) acts as an agonist of IL-6 activity. In the IL-6R/CD126/IL6R system, both a membrane-bound IL-6R and a sIL-6R protein are able to mediate IL-6 signals into the cells through the interaction of gp13. The resulting IL-6/sIL-6R protein complex is also capable of binding to gp13 and inducing intracellular signalling. Through this so-called 'trans-signalling' mechanism, IL-6 is able to stimulate cells that lack an endogenous mIL-6R. High levels of IL-6 and sIL-6R have been reported in several chronic inflammatory and autoimmune diseases as well as in cancer.

IL-6R References

  • Barill S, et al. (2000) The role of interleukin-6 and interleukin-6/interleukin-6 receptor-alpha complex in the pathogenesis of multiple myeloma. Eur Cytokine Netw. 11(4): 546-51.
  • Kang KW, et al. (2007) Novel role of IL-6/SIL-6R signaling in the expression of inducible nitric oxide synthase (iNOS) in murine B16, metastatic melanoma clone F10.9, cells. Free Radic Biol Med. 42(2): 215-27.
彩票大奖得主捐赠 湖北十一选五手机版 至尊国际棋牌官网下载 网络赚钱方法 全国最知名的股票配资平台 江苏十一选五规律技巧 福彩p62怎么玩法 股票怎么看k线图视 做个棋牌app多少 宝牛e配资 绿码数字在其中什么肖