Fc Receptor / Fc Receptors

Fc receptor types & molecules

Fc Receptor binding IgA

Fc Receptor binding IgE

Fc Receptor-Like Receptor

Fc Receptor binding IgA&IgM

Fc receptor background

Fc receptor is a protein belonging to immunoglobulin superfamily that contributes to the protective functions of the immune system. Fc receptor is found on the surface of certain cells - including B lymphocytes, natural killer cells, macrophages, neutrophils and mast cells. Its name is derived from its binding specificity for a part of an antibody known as the Fc portion. Fc receptors bind to antibodies that are attached to infected cells or invading pathogens. There are many kinds of Fc receptor based on the type of antibody that they recognize. Their activity stimulates phagocytic or cytotoxic cells to destroy microbes or infected cells by antibody-mediated phagocytosis or antibody-dependent cell-mediated cytotoxicity.

What is Fc receptor

Fc receptor is a protein belonging to immunoglobulin superfamily that contributes to the protective functions of the immune system. Fc receptor can bind to fc portion of antibody. There are many kinds of Fc receptor based on the type of antibody that they recognize.More…

Fc receptor function

Fc receptors are found on a number of cells in the immune system including phagocytes like macrophages and monocytes, granulocytes like neutrophils and eosinophils and lymphocytes of the innate immune system (natural killer cells) or adaptive immune system (e.g., B cells). They allow these cells to bind antibodies that are attached to the surface of microbes or microbe infected cells, helping these cells to identify and eliminate microbial pathogens. Activation of phagocytes is the most common function attributed to Fc receptors.More…

Classes of fc receptor

Fc receptor have been isolated and they are classified into different types based on the type of antibody that they recognize. More…

Fc alpha receptor (FCAR / FcαR)

Fc alpha receptor (FcαR) is the receptor specific for IgA which binds IgA with low affinity. There is only one type belonging to the Fc alpha receptor subgroup, which is called FcαRI (CD89/FCAR/FcαR). Fc alpha receptor I is expressed on neutrophils, eosinophils, monocytes/macrophages, dendritic cells and Kupffer cells.More…

Fc gamma receptor (FCGR / FcγR)

Fc gamma receptor (FcγR) is a receptor for the Fc portion of IgG. There are three major classes of Fc gamma receptor receptors. For example, CD64 (FCGRI / FcγRI), CD32 (FCGRII / FcγRII), CD16 (FCGRIII / FcγRIII). All of the Fc gamma receptors (FcγR) belong to the immunoglobulin superfamily. Fc gamma receptor is essential participant in many immune system effector functions, such as phagocytosis of opsonized, release of inflammatory mediators and antibody-dependent cellular cytotoxicity.More…

Fc epsilon receptor (FCER / FcεR)

Fc epsilon receptor (FcεR) is a Fc receptor that binding IgE. There are two classes of FcεRs on cells of the immune system. The high-affinity receptor, Fc epsilon receptor I (FcεRI / FCERI), which is capable of binding monomeric IgE. The low-affinity receptor, Fc epsilon receptor II (FcεRII / CD23 / FCERII) which interacts preferentially with complex IgE. More…

Neonatal Fc receptor (FCGRT)

Neonatal Fc receptor is kind of MHC class-I receptor. The neonatal Fc receptor (FCGRT) was first discovered in rodents. Further studies revealed a similar receptor in humans. In rodents, neonatal Fc receptor in the neonatal gut epithelium and fetal yolk sac transports maternal IgG to the neonate and in humans neonatal Fc receptor mediates maternal-fetal IgG transport across the placenta. More…

Fc Receptor-Like protein (FCRL / FCRH)

FCRL is a Fc Receptor-Like protein and is a subfamily of the five Ig superfamily members. FCRL is also called Fc Receptor Homolog (FCRH). The genes of FCRLs locate on human chromosome 1 and mouse chromosome 3. The genes of FCRLs have also been identified as immunoglobulin superfamily receptor translocation associated (IRTA) genes, SH-2 domain-containing phosphatase anchor proteins (SPAP) genes. FCRLs have sequence homology with the classical Fc receptor for IgG, FCGRI, FCGRII and FCGRIII. Members of FcRH1-5 subfamily belong to the network of receptors that possess immunoreceptor tyrosinebased activating motifs (ITAM), inhibition motifs (ITIM) or both. Their functions are as an activating coreceptor in B-cells and promoting B-cells activation and differentiation. More…

Fcα/μR (FCAMR)

Fcα/μ receptor (Fcα/μR) is a novel Fc receptor for IgM and IgA (FCAMR), designated, which might be involved in IgM-mediated immune defenses against infection. Fcα/μR is a new member of Fc receptors, whose gene is closely located at the polymeric immunoglobulin receptor (poly-IgR) in the Fc receptor gene cluster on the chromosome 1. The Fcα/μR is constitutively expressed on the majority of B-lymphocytes and macrophages in the spleen and at the center of the secondary lymphoid follicles. The Fcα/μR mediates endocytosis immune complexes of Staphylococcus aureus/anti-S. aureus IgM antibody by B-lymphocytes. These results reveal a new mechanism in the primary stage of immune defense against microbes. More…

Fc receptor references

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12. Andrew G,?et al.?(2006) International Immunology18(9):1363-1373.
13. S. Honda,?et al.?(2005) International Congress Series1285:78-83.

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