C7 (Protein | Antibody | cDNA Clone | ELISA Kit)

All C7 reagents are produced in house and quality controlled, including 4 C7 Antibody, 1 C7 ELISA, 15 C7 Gene, 2 C7 Lysate, 2 C7 Protein, 1 C7 qPCR. All C7 reagents are ready to use.

More Product Popular With Customers

C7 Background

Complement component 7 is a component of the complement system. It belongs to the complement C6/C7/C8/C9 family. It contains 1 EGF-like domain, 1 LDL-receptor class A domain, 1 MACPF domain, 2 Sushi (CCP/SCR) domains and 2 TSP type-1 domains. Complement component 7 serves as a membrane anchor. It participates in the formation of Membrane Attack Complex (MAC). People with C7 deficiency are prone to bacterial infection. It is a constituent of MAC that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. Defects in C7 are a cause of complement component 7 deficiency (C7D). A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis.

C7 References

  • Bossi F, et al. (2009) C7 is expressed on endothelial cells as a trap for the assembling terminal complement complex and may exert anti-inflammatory function. Blood. 113(15):3640-8.
  • Kuijpers TW, et al. (2010) Complement factor 7 gene mutations in relation to meningococcal infection and clinical recurrence of meningococcal disease. Mol Immunol. 47(4):671-7.
  • Thomas AD, et al. (2012) Characterization of a large genomic deletion in four Irish families with C7 deficiency. Mol Immunol. 50(1-2):57-9.
彩票大奖得主捐赠 大跌的股票有大涨的 极速赛车骗局全过程 体彩大乐透玩法中奖方式 2020适合投资的理财方式 极速直播11选5开奖视频 黑龙江十一选五遗漏 股市交流平台 快乐10分钟开奖结果 福建十一选五开奖结果查询结果 深圳 股票融资